Two problems with the same fix, so I've bulked them together. If you find that you can't overwrite saves, or if the game crashes when you try to go to Vienna, then try this. It fixed my problem.
1. First download and install the patch:
Mirror 1: http://www.megaupload.com/?d=XG08Z1RC
Mirror 2: http://www.4shared.com/file/-UVihOB9/VampirePatch.html
2. Find the install folder (usually C:\Program Files\Vampire The Masquerade - Redemption).
3. Right-click the folder and click Properties. In the properties box click Advanced (in the attributes section). Make sure "For fast searching, allow indexing service to index this folder" is ticked. Then click ok. If you are asked make sure it is applied to all sub-folders.
4. Make sure that the Indexing Service is set to automatic. To check this click start then run. In the run box type in services.msc and press enter. Scroll down the list to find the Indexing Services.
Doing this should stop any problems.